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1. Involvement of metformin and aging in salivary expression of ACE2 and TMPRSS2 NSTL国家科技图书文献中心

Shikama, Yosuke |  Otsuka, Kunihiro... -  《BioFactors》 - 2025,51(1) - n/a~n/a - 共13页

摘要: epithelial cells and the lungs. Regarding TMPRSS2, zymogen |  salivary glands, whereas only zymogen was expressed in | SARS-CoV-2-related proteins, ACE2 and TMPRSS2 | , are determinants of SARS-CoV-2 infection. Although |  these proteins are expressed in oral-related tissues
关键词: ADAM17 |  epithelial cells |  saliva |  salivary glands |  SARS-CoV-2 |  SARS‐CoV‐2

2. A High-Throughput Cell-Free Enzyme Screening System Using Redox-Responsive Hydrogel Beads as Artificial Compartments NSTL国家科技图书文献中心

Koga, Taisei |  Okawa, Yui... -  《ACS Synthetic Biology》 - 2025,14(3) - 995~1001 - 共7页

摘要: zymogen (MTGz) using cell-free protein synthesis and the | We have developed a rapid, simple, and high | -throughput screening system for recombinant enzymes using |  disulfide-bonded hydrogel beads (HBs) produced via a |  microfluidic method. These redox-responsive HBs were
关键词: cell-free protein synthesis |  fluorescence-activateddroplet sorter |  high-throughput screening |  hydrogelbeads |  microbial transglutaminase |  next-generationsequencing

3. Prethrombin-1 as a Drug Substance Promoting Hemostasis with Reduced Risk of Thrombosis NSTL国家科技图书文献中心

Graus, Johann Georg |  Prueckler, Michael... -  《Thrombosis and Haemostasis》 - 2025,125(1) - 36~45 - 共10页

摘要:. Conclusion The thrombin zymogen prethrombin-1 promotes | Introduction Prethrombin-1 is a Gla-domain |  lacking enzymatically inactive split product that |  results from the cleavage of fragment 1 from prothrombin |  by thrombin in a feedback reaction. Methods A
关键词: coagulation |  vitamin K-dependent proenzyme |  clotting factors |  prothrombin |  prethrombin-1

4. Chemerin in immunity NSTL国家科技图书文献中心

Laffranchi, Mattia |  Schioppa, Tiziana... -  《Journal of Leukocyte Biology》 - 2025,117(3) - qiae181~qiae181 - 共15页

摘要: zymogen that needs to be proteolytically activated to | Chemerin is a distant member of the cystatin |  protein family, initially discovered as a chemotactic |  factor and subsequently also reported to act as |  adipokine and angiogenetic factor. The biological activity
关键词: cancer |  CCRL2 |  chemerin |  CMKLR1 |  inflammation

5. Diagnostic Accuracy of Novel Protein Biomarkers in Saliva to Detect Periodontitis Using Untargeted 'SWATH' Mass Spectrometry NSTL国家科技图书文献中心

Blanco-Pintos, T. |  Regueira-Iglesias, A...... -  《Journal of clinical periodontology》 - 2025,52(2) - 199~214 - 共16页

摘要:-microglobulin with profilin-1, and lysozyme C with zymogen | Aim: To discover new salivary biomarkers to |  diagnose periodontitis and evaluate the impact of age and |  smoking on predictive capacity. Material and Methods | : Saliva samples were collected from 44 healthy
关键词: diagnostic accuracy |  molecular biomarkers |  periodontitis |  proteomics |  SWATH-MS |  SWATH‐MS

6. Structural insights into the role of the prosegment binding loop in a papain-superfamily cysteine protease from Treponema denticola NSTL国家科技图书文献中心

Clark, N. D. |  Li, C.... -  《Acta crystallographica,Structural biology communications.Section F》 - 2025,81(2) - 53~61 - 共9页

摘要: produced as proenzymes with a prodomain that interacts |  proenzyme, suggesting an alternative regulatory mechanism | Periodontal diseases afflict 20-50% of the |  global population and carry serious health and economic |  burdens. Chronic periodontitis is characterized by
关键词: bacterial virulence factors |  papain-superfamily cysteine proteases |  X-ray crystal structure |  immune evasion |  protease regulation

7. Cysteine Peptidases of Calotropis procera (Apocynaceae): A Literature Review on their Biochemical Properties and Potential Applications NSTL国家科技图书文献中心

Beatriz Nogueira |  Filipe de Abreu Viei...... -  《Current Protein and Peptide Science》 - 2025,26(4) - 296~307 - 共12页

摘要: cysteine peptidase zymogens have been shown to be | The latex of the xerophytic plant Calotropis |  procera , popularly known as giant milkweed, contains a |  complex mixture of secondary metabolites and proteins |  and has attracted the attention of many researchers
关键词: Latex |  cysteine peptidases |  Calotropis procera |  purification |  biochemical properties |  potential applications.

8. RASEF/Rab45 regulates the formation and sorting of zymogen granules and secretion of digestive enzymes by pancreatic acinar cells NSTL国家科技图书文献中心

Sato K. |  Kadowaki T.... -  《Biochimica et biophysica acta. Molecular basis of disease: BBA》 - 2024,1870(7) - 167310~167310 - 共6页

摘要: trafficking, in pancreatic exocytosis of zymogen granules in |  number of zymogen granules and abnormal formations of |  likely regulates the formation and sorting of zymogen | ? 2024 The Author(s)The pancreas is a |  glandular organ with both endocrine and exocrine functions
关键词: Organelle formation |  Pancreas |  Rab45 |  RASEF |  Zymogen granules

9. Sensitive detection of SARS‐CoV‐2 main protease 3CLpro with an engineered ribonuclease zymogen NSTL国家科技图书文献中心

Evans C. Wralstad |  Ronald T. Raines -  《Protein science :》 - 2024,33(4) - e4916~e4916 - 共6页

摘要: create a circular ribonuclease zymogen that is |  activated by the SARS‐CoV‐2 main protease, 3CLpro. Zymogen | Abstract Alongside vaccines and antiviral |  therapeutics, diagnostic tools are a crucial aid in combating |  the COVID‐19 pandemic caused by the etiological
关键词: circular protein |  COVID‐19 |  function‐based diagnostic |  protease |  rapid antigen detection testing |  ribonuclease |  SARS‐CoV‐2 |  zymogen

10. Engineering the Propeptide of Microbial Transglutaminase Zymogen: Enabling Substrate-Dependent Activation for Bioconjugation Applications NSTL国家科技图书文献中心

Ariyoshi, Ryutaro |  Matsuzaki, Takashi... -  《Bioconjugate Chemistry》 - 2024,35(3) - 340~350 - 共11页 - 被引量:1

摘要: MTG zymogen (MTGz) in the biosynthesis. Herein, we |  report engineered active zymogen of MTG (EzMTG) that is | Microbial transglutaminase (MTG) from |  Streptomyces mobaraensis is a powerful biocatalytic glue for |  site-specific cross-linking of a range of
关键词: SITE-SPECIFIC CONJUGATION |  STREPTOMYCES-MOBARAENSIS |  PROTEIN CONJUGATION |  ESCHERICHIA-COLI |  ENZYME |  ANTIBODY |  STREPTOVERTICILLIUM |  PHARMACOKINETICS |  PURIFICATION |  EXPRESSION
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