NSTL国家科技图书文献中心

1. SUMO Regulation of Ion Channels in Health and Disease NSTL国家科技图书文献中心

Connolly, Jenna G. | Plant, Leigh D. - 《Physiology》 - 2025,40(2) - 158～173 - 共16页

摘要：The small ubiquitin-like modifier (SUMO | ) protein pathway governs a panoply of vital biological | processes including cell death, proliferation | , differentiation, metabolism, and signal transduction by | diversifying the functions, half-lives, and partnerships of

关键词： ion channels | posttranslational modification | SUMOylation | Ubc9 | UbL

2. Olfactory Development and Dysfunction: Involvement of Microglia NSTL国家科技图书文献中心

Meller, Sarah J. | Greer, Charles A. - 《Physiology》 - 2025,40(2) - 174～184 - 共11页

摘要：Olfactory deficits are increasingly recognized | in a variety of neurological, neurodevelopmental | , psychiatric, and viral diseases. While the pathology | underlying olfactory loss is likely to differ across | diseases, one shared feature may be an immune response

关键词： development | disease | immune system | microglia | olfaction

3. Factors Contributing to Heat Tolerance in Humans and Experimental Models NSTL国家科技图书文献中心

Laitano, Orlando | Oki, Kentaro ... - 《Physiology》 - 2025,40(1) - 37～45 - 共9页

摘要：Understanding physiological mechanisms of | tolerance to heat exposure, and potential ways to improve | such tolerance, is increasingly important in the | context of ongoing climate change. We discuss the | concept of heat tolerance in humans and experimental

关键词： climate change | exercise | heat stress | mouse model | thermoregulation

4. mTORC1 and 2 Adrenergic Regulation and Function in Brown Adipose Tissue NSTL国家科技图书文献中心

Festuccia, William T... - 《Physiology》 - 2025,40(2) - 134～144 - 共11页

摘要：Brown adipose tissue (BAT) thermogenesis | results from the uncoupling of mitochondrial inner | membrane proton gradient mediated by uncoupling protein 1 | (UCP-1), which is activated by lipolysis-derived | fatty acids. Norepinephrine (NE) secreted by

关键词： brown adipose tissue | mTORC1 | mTORC2

5. Piezo1: the Force Awakens-How Red Blood Cells Sense and Respond to Mechanical Stress NSTL国家科技图书文献中心

Kuck, Lennart - 《Physiology》 - 2025,40(2) - 117～117 - 共1页

摘要：“Mechanotransduction” is a term I would use to | describe my research topic, and it works perfectly well | , as long as the goal is to earn confused looks and | immediately suffo cate the conversation about what I study | in the laboratory. Technical language is a common

关键词： calcium signaling | mechanotransduction | Piezo1 | red blood cells | science communication

6. Predictors of Inflammation-Mediated Preterm Birth NSTL国家科技图书文献中心

Georges, Hanah M. | Norwitz, Errol R.... - 《Physiology》 - 2025,40(1) - 26～36 - 共11页

摘要：Preterm birth remains a worldwide health | concern because of ongoing challenges in prediction and | prevention. Current predictors are limited by poor | performance, need for invasive sampling, and an inability to | identify patients in a timely fashion to allow for

关键词： biomarkers | inflammation | predictors | pregnancy | preterm birth

7. Microtubule Reorganization and Quiescence: an Intertwined Relationship NSTL国家科技图书文献中心

Laporte, Damien | Sagot, Isabelle - 《Physiology》 - 2025,40(2) - 145～157 - 共13页

摘要：Quiescence is operationally defined as a | reversible proliferation arrest. This cellular state is | central to both organism development and homeostasis | , and its dysregulation causes many pathologies. The | quiescent state encompasses very diverse cellular

关键词： microtubule | primary cilium | quiescence | stem cells | yeast

8. Mechanical Remodeling of Nuclear Biomolecular Condensates NSTL国家科技图书文献中心

Soggia, Giulia | Elmaghloob, Yasmin ... - 《Physiology》 - 2025,40(1) - 102～113 - 共12页

摘要：Organism health relies on cell proliferation | , migration, and differentiation. These universal processes | depend on cytoplasmic reorganization driven notably by | the cytoskeleton and its force-generating motors | . Their activity generates forces that mechanically

关键词： aging | biomolecular condensates | cancer | cytoskeleton | nucleus | oocytes

9. Beyond ATP: Metabolite Networks as Regulators of Physiological and Pathological Erythroid Differentiation NSTL国家科技图书文献中心

Joly, Axel | Schott, Arthur ... - 《Physiology》 - 2025,40(1) - 88～101 - 共14页

摘要：Hematopoietic stem cells (HSCs) possess the | capacity for self-renewal and the sustained production of | all mature blood cell lineages. It has been well | established that a metabolic rewiring controls the switch of | HSCs from a self-renewal state to a more

关键词： erythroid differentiation | hematopoiesis | metabolic therapeutic strategies | metabolism | pathological erythropoiesis

10. Role of RANKL Signaling in Bone Homeostasis NSTL国家科技图书文献中心

Sobacchi, Cristina | Menale, Ciro ... - 《Physiology》 - 2025,40(1) - 46～66 - 共21页

摘要：RANKL and its cognate receptor RANK are | crucial regulators of bone metabolism in physiological | as well as in pathological conditions. Here we go | through the works that unveiled the paramount role of | this signaling pathway. We focus on the RANKL