Raeber, Miro E. |  Caspar, Dominic P.... -  《Immunity》 - 2024,57(9) - 共30页

摘要：Due to its stimulatory potential for immunomodulatory CD4(+) regulatory T (Treg) cells, low-dose interleukin-2 (IL-2) immunotherapy has gained considerable attention for the treatment of autoimmune di...

关键词： LOW-DOSE INTERLEUKIN-2 |  SYSTEMIC-LUPUS-ERYTHEMATOSUS |  THERAPY |  IL-2 |  MECHANISMS |  AUTOIMMUNE |  DISEASE |  DIFFERENTIATION |  VISUALIZATION |  STIMULATION

Fan, Zheng |  Ardicoglu, Raphaela... -  《Angiogenesis》 - 2023,26(3) - 385～407 - 共23页 - 被引量：4

摘要：The molecular mechanisms of angiogenesis have been intensely studied, but many genes that control endothelial behavior and fate still need to be described. Here, we characterize the role of Apold1 (Ap...

关键词： Angiogenesis |  Endothelial cell |  EC proliferation |  Hindlimb ischemia |  Stroke |  Tumor |  MOLECULAR REGULATION |  PROFILING REVEALS |  RNA-SEQ |  EXPRESSION...

Arora, Ankita |  Castro-Gutierrez, Ro...... -  《Nucleic Acids Research》 - 2022,50(18) - 10626～10642 - 共17页 - 被引量：14

摘要：Hundreds of RNAs are enriched in the projections of neuronal cells. For the vast majority of them, though, the sequence elements that regulate their localization are unknown. To identify RNA elements ...

关键词： MESSENGER-RNA |  REVEALS |  PROTEIN |  APC

Mikl, Martin |  Eletto, Davide... -  《Nucleic Acids Research》 - 2022,50(18) - 10643～10664 - 共22页 - 被引量：7

摘要：Asymmetric subcellular mRNA localization allows spatial regulation of gene expression and functional compartmentalization. In neurons, localization of specific mRNAs to neurites is essential for cellu...

关键词： MESSENGER-RNA |  SYSTEMATIC DISSECTION |  GENE-EXPRESSION |  WEB SERVER |  LONG RNAS |  BINDING |  TRANSLATION |  PROTEIN |  TRANSCRIPTOME |  ARCHITECTURE

Harnik, Yotam |  Buchauer, Lisa... -  《Nature Metabolism》 - 2021,3(12) - 1680～+ - 共28页 - 被引量：24

摘要：Harnik and Buchauer et al. identify spatial discordances between enterocyte mRNA and protein levels along the villi of the small intestine, and provide a spatial blueprint of proteins in the intestina...

关键词： CELL-POPULATIONS |  SELF-RENEWAL |  STEM-CELLS |  DIFFERENTIATION |  IDENTIFICATION |  PEROXISOMES

Ducimetiere, Laura |  Lucchiari, Giulia... -  《Proceedings of the National Academy of Sciences of the United States of America.》 - 2021,118(27) - e2026271118～e2026271118 - 共12页 - 被引量：46

摘要：The liver isa major metastatic target organ, and little is known about the role of immunity in controlling hepatic metastases. Here, we discovered that the concerted and nonredundant action of two inn...

关键词： innate lymphocytes  |  metastatic surveillance  |  tissue-resident ILC1s  |  conventional NK cells |  NATURAL-KILLER-CELL |  TRANSCRIPTION FACTOR E4BP4 |  INNATE LYMPHOID-CELLS |  IMMUNE CELLS |  T-BET |  CANCER...

Healy, Marc E. |  Boege, Yannick... -  《Gastroenterology》 - 2020,159(1) - 183～199 - 共17页 - 被引量：18

摘要：BACKGROUND & AIMS: Intestinal epithelial homeostasis depends on a tightly regulated balance between intestinal epithelial cell (IEC) death and proliferation. While the disruption of several IEC death ...

关键词： Colorectal Carcinoma |  CRC |  Cell Death |  Tumorigenesis

Zurbuchen, Yves |  Michler, Jan... -  《Nature immunology》 - 2023,24(11) - 1961～1961 - 共1页

Bouwman, Britta A. M... |  Agostini, Federico... -  《Nature protocols erecipes for researchers》 - 2020,15(12) - 3894～3941 - 共48页 - 被引量：12

摘要：sBLISS (in-suspension breaks labeling in situ and sequencing) is a versatile and widely applicable method for identification of endogenous and induced DNA double-strand breaks (DSBs) in any cell type ...

Jarret, Abigail |  Jackson, Ruaidhri... -  《Cell》 - 2020,180(4) - 813～814 - 共2页 - 被引量：23