Anshuman Pa |  Jeffrey A. Rosenfeld... -  《Oncoimmunology.》 - 2020,9(1) - art. no. 1756116～art. no. 1756116 - 共7页 - 被引量：11

摘要：Immune checkpoint blockade leads to unprecedented responses in many cancers. Although currently available agents mostly target the PD-1 and CTLA-4 pathways, agents targeting the immune checkpoint prot...

关键词： Immune checkpoint blockade |  LAG-3 |  mutation burden |  virus |  endogenous retrovirus

Raul Rabadan |  Gyan Bhanot... -  《Journal of Statistical Physics》 - 2018,172(1) - 143～155 - 共13页 - 被引量：5

摘要：One cause of cancer mortality is tumor evolution to therapy-resistant disease. First line therapy often targets the dominant clone, and drug resistance can emerge from preexisting clones that gain fit...

关键词： 87.23.Kg |  87.18.Tt |  87.18.Wd |  87.18.Vf |  02.50.-r

Gargi Mukherjee |  Gyan Bhanot... -  《2016 IEEE Congress on Evolutionary Computation: CEC 2016, Vancouver, British Columbia, Canada, 24-29 July 2016, pages 1-761, [v.1]》 -  IEEE Congress on Evolutionary Computation - 2016, - 656～661 - 共6页

摘要：Using mRNA-Seq and clinical data for 469 clear cell Renal Cell Carcinoma (ccRCC) samples from The Cancer Genome Atlas (TCGA), we develop a protocol to identify patients likely to have early recurrence...

关键词： Cancer |  Training |  Prototypes |  Biology |  Drugs |  Biomarkers

NSTL主题词： Clear Cell Renal Cell Carcinoma |  outliers |  Relapse

Kerri-Ann Norton |  Mariko Fujibayashi... -  《2012 IEEE-EMBS conference on biomedical engineering and sciences: IECBES 2012, 17-19 December 2012, Langkawi, Malaysia, pages 519-1033, [v.2]》 -  IEEE-EMBS Conference on Biomedical Engineering and Sciences - 2012, - 631～635 - 共5页

摘要：Ductal Carcinoma in situ (DCIS) is a pre-invasive carcinoma of the breast that exhibits several distinct morphologies. The staging of the disease is often based on 2-dimensional (2D) slices from tissu...

关键词： Registration |  Segmentation |  Breast cancer |  Image processing

Michael Seiler |  C. Chris Huang... -  《OMICS: A journal of integrative biology》 - 2010,14(1) - 109～113 - 共5页 - 被引量：45

摘要：We have created a stand-alone software tool, ConsensusCluster, for the analysis of high-dimensional single nucleotide polymorphism (SNP) and gene expression microarray data. Our software implements th...

关键词： robust clusters |  a consensus matrix heatmap |  biological interpretation

GABRIELA ALEXE |  GUL S. DALGIN... -  《Genome informatics 2007》 -  International Workshop on Bioinformatics and Systems Biology - 2007, - 130～140 - 共11页

摘要：We describe a new method based on principal component analysis and robust consensus ensemble clustering to identify and elucidate the subtypes of breast cancer disease. The method was applied to micro...

关键词： breast cancer;;microarray analysis;;disease subtypes;;progression;;principal component analysis;;consensus ensemble clustering

Gyan Bhanot |  Gabriela Alex -  《Genome informatics 2005》 -  Genome informatics 2005 - 2005, - 233～244 - 共12页

摘要：A major challenge in cancer diagnosis from microarray data is the need for robust, accurate, classification models which are independent of the analysis techniques used and can combine data from diffe...

关键词： meta-classifier |  feature selection |  pattern |  p53 |  gene expression |  lymphom

Gyan Bhanot -  《Brain-inspired computing: International Workshop, BrainComp 2013, Cetraro, Italy, July 8-11, 2013, Revised Selected Papers》 -  International Workshop on Brain-Inspired Computing - 2014, - 15～21 - 共7页

摘要：I describe the evolution of life and the evolution of complex dynamical systems such as the brain as an emergent phenomenon, which allow a subset of multicellular life to learn its environment and ada...

NSTL主题词： Cerebrum |  Genes |  machine |  machinery |  RNA

Caleb F Davis |  Christopher J Ricket...... -  《Cancer Cell》 - 2014,26(3) - 319～330 - 共12页

摘要：We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell carcinomas (ChRCCs) on the basis of multidimensional and comprehensive characterization, including mtDNA and whole...

Anupama Reddy |  A. Rose Brannon... -  《BIOCOMP 2009: Proceedings of the 2009 International Conference on Bioinformatics and Computational Biology, v.2》 -  International Conference on Bioinformatics and Computational Biology - 2009, - 441～447 - 共7页

摘要：We present a simple score to predict survival for cancer patients using an algorithm which identifies gene expression patterns correlated with survival. We illustrate our method using a published micr...